Neurobiology of Disease Imipramine Treatment and Resiliency Exhibit Similar Chromatin Regulation in the Mouse Nucleus Accumbens in Depression Models
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چکیده
Matthew B. Wilkinson,1* Guanghua Xiao,2* Arvind Kumar,3* Quincey LaPlant,1 William Renthal,2 Devanjan Sikder,4 Thomas J. Kodadek,4 and Eric J. Nestler1 1Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029-6574, Departments of 2Clinical Sciences, 3Psychiatry, and 4Internal Medicine and Division of Translational Research, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390
منابع مشابه
Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models.
Although it is a widely studied psychiatric syndrome, major depressive disorder remains a poorly understood illness, especially with regard to the disconnect between treatment initiation and the delayed onset of clinical improvement. We have recently validated chronic social defeat stress in mice as a model in which a depression-like phenotype is reversed by chronic, but not acute, antidepressa...
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تاریخ انتشار 2009